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These persister cells exhibit a reversible, non-genetic phenotypic trait unrelated to heritable drug resistance mutations, with their progeny restoring wild-type antifungal susceptibility, and the biofilm-specific niche is confirmed to be essential for their formation (LaFleur et al., 2006)

Oral administration in neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and rotenone induced rodent models dose-dependently improved motor function, preserved striatal dopamine and tyrosine hydroxylase levels, and reduced DA neuron loss (Maher, 2021